I don't think that the Tyrant does as well in Chaos Knights as it does in Imperial Knights.
You can run three big knights and four little knights as a basic template. Or two big knights and 7-9 little knights. A lot depends on what options you have for the weapons. Maegera knights work well with Chaos, though you can only give one warlord traits and relics if you make it your Warlord. I'm not personally a fan of the Warglaive style War Dogs, but you may not have the option to make them Moirax with the lightning locks.
On a more basic level, Infernal Knight Households shoot better, and the Iconoclast Households hit harder in melee. Both have some fun options to go with. For right now, the basic Warlord trait Infernal Quest is awesome, as it gives one knight ObSec and counts as 10 models.
Right now, I am planning on running a mono knights list of Infernal House Khomentis with two Magaera, one double gatling knight, and three lightning-lock moirax. This leaves me 45 points free to summon in a pack of 5 furies at some point, since its hard to spend a measly 50 points on knights sometimes.
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