The resin used is a lightweight, fairly soft material (as resin goes - it's not rubbery, but not super hard and brittle), and the human sized models are only fractionally heavier than human figures. So no, getting knocked over on the table is no more an issue than it would be for plastic models, although I have seen these cause problems with harder, more brittle resins.
Getting knocked off the table to a hard floor might be an issue, depending on the model, but it's mainly long, thin components that would be at risk - and they tend to snap cleanly when they break, so are easily glued back together.
Basically, yes, resin is slightly less forgiving than plastic, but the minis are still being made for gaming, and the resin used reflects that.
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