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And also, is there any explanation for where they come from?

The limit should be 0. Stupid concept.

I don't think there's ever been any limit placed on them. There's also absolutely no explanation. Not even any hint of a suggestion, AFAIK, which is one of the more annoying things about them.

I suspect that the explanation might turn out to be something along the lines of the Sensei from Rogue Trader - biological children of the Emperor
('Oh no! Horus zapped my real son! That'll give me a second wind!')

Some are naturally occurring, and believe themselves to be the next stage in human evolution.

Others are artificially created - the Emperor and Xenos have both created them.

There can be only one!

Sorry, wrong franchise.

They just kind of exist. Mutants that live a long time and regenerate. They can be natural or artificial and I believe it's one of those things the Old Ones could do with their super high tech and magic powers. Erebus did it using an ancient ritual to bring Argel Tal's favourite person back to life.

 Lord Damocles wrote:
I suspect that the explanation might turn out to be something along the lines of the Sensei from Rogue Trader - biological children of the Emperor
('Oh no! Horus zapped my real son! That'll give me a second wind!')

Saturnine spoilers