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I'm running a 1500 point IG list, primarily a gunline with 2 bassies, drop plasma/melta, and a min-size Inquisitor Lord for 'Hood support. The full list can be found here.

I'm hitting about .500 in tourney play with it, so I'm looking to tweak it. My question is is it worth it to swap out the 2X Special Weapon squads (1 Demo + 2 Flamers each) for a Callidus Assassin?

If you have to choose between them, take the Callidus. Word in Your Ear is worth half her points all by itself. Add the Tarot to your (DaemonHunter) Inq for the potential +1 to go first and it can be fun fun fun!!