Shikome should very easily hurt Nino.
I don't play Kirai (or any rezzers for that matter), but one thing I've seen her oftentimes do is take a ton of cheap Spirits such as Seishin. Activate those one at a time and waste their activations. Once the entirety of their important models have activated, activate your important models such as the Shikome and Kirai herself. Those cheap spirits also double as a decent sacrifice for healing Kirai (which you will be doing a lot).
Obviously watch your hand size when going against Nino. Ikiyro likes making you discard.
Witchling Stalkers' explosions only deal 1 damage to Spirits if I'm not mistaken. You can mostly ignore them. Their magical weapons are the bigger problem.
You probably already know about the Pull-My-Finger-Wiki:
http://pullmyfinger.wikispaces.com/Shikome
It may be helpful.