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1. You may use zenithal priming on any type of miniature. Size is immaterial. Although, admittedly, once you get to 75mm scale or up, the details of the model itself become large enough to cast their own shadows, and zenithal priming is probably used then to achieve a higher contrast paintjob. I admit, while I have 75mm, 90mm, and120mm models, I have never tried painting them before. 54mm models enjoy the same benefits of zenithal priming as the smaller, more common scales.
2. The objective of zenithal priming is to produce high contrasts on your model, so it is easy to identify areas of shading and areas of highlighting. In theory, I suppose that as long as your chosen colour scheme maintains such a high contrast, it would function as expected.
3. Depends on the primer or undercoat you use. I use a mix of GW Chaos Black Primer and Tamiya Fine Spray White over that, and I run that one after another, once my Chaos Black has dried.
I believe some primers are actual primers, rather than a simple undercoat like Chaos Black, and so would necessitate a curing period before a second coat. I have no knowledge of this at present, so am unable to comment.
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