Yes, I have had nearly 72 hour prints and just let it go, checking periodically that there are no plugs or snags, which certainly happen 3/4 into a long print and the whole thing is ruined.
I find on my Ender 3 Pro pausing the print is not as effective as (horror!) simply unplugging the machine. It will allow you to resume right where you left off with no real visible issue. I have had to do this when I had to leave for an extended time and was not comfortable letting the print run unobserved.
However, I will say on some really long print runs where I did have a failure I was able to slice the stl at the point of failure (3D Builder is superb for this) and run that separately and just glue them together. This has saved quite a few large, long prints that I would have had to trash and start over.
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