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Best build for all comers?

Bike Lord with MoN, PF, Claw, Sigil, Gift of Mutation, VotLW
Sorcerer, Bike, Sigil, Spell Familiar, Mastery Level Three (rolling for invisibility)

Plague Marines, 7 total models, Rhino, Dirge Caster, Power Axe, Melta Bombs, 2 Melta Guns, three squads of these fat bastards

Heldrakes with Flamers, two of these
Bike Squad,six total models,MoN,Melta Bomb,2 Melta Guns, joined with Lord and Sorcerer

Obliterator, MoN, two of these, separate units, deep striking or placed first turn depending on game/deployment

Aegis Defense Line with Comms Relay, to make sure Heldrakes come in ASAP

I play a lot SM bikers, Eldar,and Tyranids. I'm hoping to tweak this list in the best possible way for tournaments.

TIA.

How will you kill an enemy flyer as it ravages your army?

I would take the hades autocannon on one of yours and make it a dogfighter drake

EDIT: My post was a tad resenting towards Codex: Nurgle and I made it a little more friendly

Is skipping out on 5 points for a powerfist better than a power axe and meltabomb?

Plague champs already get plague knives.

Vector Strike will help with the other flyers. I'd love to have a guad gun,but I don't have the points unless I drop stuff,which is always an option. I really need the baleflamers for the bikes that I will most certainly face. I'm not sold on the power axes on the champions. However,they never seem to pack enough punch when they get assaulted while sitting on objectives.

spend 5 more points to get a Power fist and drop the melta bomb.

Powerfist and no melta bombs it is!!!!!! I'm about to play some SM Bikers with a Chapter Master on bike with grav command squad,Tiggy with Grav Cents,and lots of bikes.