Well check this out:
http://www.games-workshop.com/gws/content/article.jsp?categoryId=&pIndex=1&aId=5100032a&start=2
According to that psychic power tactica you should be able to combine the effects of Aura of Despair with The Horror and Psychic Scream
You could try using a Genestealer Broodlord or two to bring down the Leadership of nearby enemies before unleashing The Horror or Psychic Scream
The problem being that Aura of Despair clearly says you activate it in the assault phase, while the other 2 are shooting attacks. So is the person who wrote the tactica a moron or is this the intended use?
Because this would actually make the Tyrant's powers more useful.