It is fairly easy to make one piece moulds for casting resin.
Two piece moulds are a bit more difficult but the main barrier is not the mould so much as creating a good master piece to create it.
There is an article here...
http://www.dakkadakka.com/wiki/en/Simple_Two-Piece_Mold_for_Casting_with_Resin
I cast the bases of my Termagants using a one piece mould I made with silicon rubber liquid moulding materials. I used a two part silicone rubber for the mould -- Rapimould Addition Cure RTV Silicone. The resin was Polyurethan Fast Cast. It is very runny and fills the mould easily, and sets quickly.
I got my rubber and resin from Tomps, a
UK company (I am in the
UK). I am sure there are plenty of companies in the USA who supply similar materials.
http://www.tomps.com/
Here are my top tips for moulding and casting.
1. Mix the mould silicone carefully and don't get air bubbles into it. If using the liquid type which takes equal amounts of both components, you can judge the amount by eye.
2. Make sure the mould is completely dry, as water reacts with the resin and makes it foam.
3. If the resin needs to be weighed for mixing, get an electronic bathroom scales so you can weigh accurately.
4. When mixing the resin, do it thoroughly but gently, to avoid air bubbles.
I found I needed to mix a minimum of 40g of resin materials, to be accurate enough to let it set properly. This was enough resin to fill five of my small moulds and have a bit left over.
Lastly, remember that these moulding and casting chemicals can be poisonous, so make sure to read the safety precautions.