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It's not detailed in the fluff much because the fluff mostly concerns itself with things that interact with the tabletop game.

Governments being overthrown by xenos infiltrators and humans trafficking xenos or xenos artefacts would be a huge thing in the Imperium. Remember, for all the exaggerated maps they show, the Imperium is a big place.

There's countless Imperial colonies all over the galaxy that go unnoticed because they are far from war zones and warp storms, so are free from notice by the Ordo hereticus and Ordo Malleus.

However, these places tend to breed bored individuals. These bored individuals would probably like to use that virtual anonymity to contact rogue traders and do some black market dealing of xenos artefacts. These relatively isolated colonies make perfect targets for things like Genestealer cult incusions, since it's an easy way to take the small Imperial force out of power for the Hive Fleet to strike a very easy target.

There's lots of things for the Ordo Xenos to do - they just don't usually concern themselves with the bigger picture of war, so they get pushed to the background. They are still important enough in the fluff to be a major branch of the Inquisition though.