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Orks, though very robust, should be susceptible to germ warfare (as evidenced by the old Virus Bomb strategem).


On the other hand, orks shed a huge amount of spores normally, and shed them en masse after death. Just like a antibiotic will kill 99% of germs, there will still be spores which are unaffected or less affected. Those spores will generate new orkoids (perhaps not orks, but squigs, etc.), most of which will retain that resistance to the germ warfare. Therefore, while the germ warfare itself will be relatively effective to defeat a particular group of orks, it will not, by itself, be sufficient to remove the threat of future ork infestations. You would need a biological agent strong enough to affect the orks (and not any populace you wanted to protect), and you'd still have to burn the corpses and cleanse the area of spores (which, for all I know, can hang around like brine shrimp larvae).

So, while it may be an effective 'one-off' strategy, bombing the green blighters and burning them afterwards tends to work about as well, and doesn't necessitate buying a new supply of bombs for the next wave.