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Here's my thoughts for a 2000 point foot IG list for an upcoming tournament:

HQ:

CCS w/ Col Straken & 4 Flamers 165

CCS w/ CC 2 Bolt Pistols & 4 Flamers 74

Troops:

PCS w/ PC BP + PF, Commissar BP + PF & 4 Flamers 117
IS w/ Sgt PW & Commissar PW 105
IS w/ Sgt PW 60
IS w/ Sgt PW 60
HWS w/ 3 Lascannons 105
HWS w/ 3 Lascannons 105
HWS w/ 3 Lascannons 105

PCS w/ PC BP + PF, Commissar BP + PF & 4 Flamers 117
IS w/ Sgt PW & Commissar PW 105
IS w/ Sgt PW 60
IS w/ Sgt PW 60
HWS w/ 3 Lascannons 105
HWS w/ 3 Lascannons 105

PCS w/ PC BP + PF, Commissar BP + PF & 4 Flamers 117
IS w/ Sgt PW & Commissar PW 105
IS w/ Sgt PW 60
IS w/ Sgt PW 60
HWS w/ 3 Lascannons 105
HWS w/ 3 Lascannons 105

Thoughts?

Without transports for the CCS's they're gonna get torn to bits, but that would be around two less infantry squads so it's either-or. The PW on the sergeants seem a bit useless, considering normal guardsmen aren't exactly top-class melee fighters. You also, aside from the command squads, lack anything to really punch through cover or armored troops like space marines.

However, most of these are just acceptable dilemmas with food armies, so yeah. It looks pretty good, and I'm not the greatest reviewer of lists, so feel free to ignore me once people who know what the gak they're talking about show up.

If it were me, I'd probably thin the lascannons out a little with MLs, or at least autocannons. Then I'd drop the commissars and everything but the flamers from your PCSs, because they're not doing any good. Here's a slimmed down version of your list:

CCS w/ Col Straken & 4 Flamers 165pts

Platoon 1 590pts
-PCS w/ 4 Flamers
-IS w/ Sgt PW & Commissar PW
-IS w/ Sgt PW
-IS w/ Sgt PW
-HWS w/ 3 Lascannons
-HWS w/ 3 Lascannons
-HWS w/ 3 Lascannons

Platoon 2 425pts
-PCS w/ 4 Flamers
-IS w/ Sgt PW & Commissar PW
-IS w/ Sgt PW
-IS w/ Sgt PW
-HWS w/ 3 Autocannons
-HWS w/ 3 Autocannons

Platoon 3 425pts
-PCS w/ 4 Flamers
-IS w/ Sgt PW & Commissar PW
-IS w/ Sgt PW
-IS w/ Sgt PW
-HWS w/ 3 Autocannons
-HWS w/ 3 Autocannons

1605pts

It's now more focused and you have almost 400pts to play with.
Some suggestions:
-Camo cloaks could work pretty well with your command squads, you can screen them with the blobs for 3+ cover
-Small storm trooper teams can put melta or plasmaguns anywhere on the board and don't have to slog like the rest of your army
-If you play with a lot of terrain, consider rough riders to apply early pressure to your opponent or protect your heavy weapons
-One possibility would be to add another squad and commissar to every platoon, so you can field them as 2x20 men or 1x40
-A veteran squad with harker could be worth looking into

You'll notice I removed your second command squad. It was just a more expensive PCS with a few orders. There would be merit to keeping a stationary command squad around to order your HWTs, but it's not a reliable tactic when you have no way of boosting their Ld. To do that, you need to either add Kell to that command squad, for two Ld9 orders per turn, or get a lord commissar to hang around them. However, if you're using straken odds are he won't be around to give those orders. A lord commissar still helps you, because HWTs have a tendency to run away if left alone, but to make better use of him I would change the command squad to something like this:

CCS: Lascannon
-Creed, Kell
-Master of ordnance
-camo cloaks

or at least this:

CCS
-Kell
-camo cloaks

With that many HWSs, Creed, Kell and a Lord Commissar are a must. Place 3-4 HWSs (I suggest the LCs) within 6" of the Lord in cover for his Aura of Discipline. Keep the other (ACs) within 24" of the CCS.

If you want Straken, you will /need/ Kell for sure, as you need a 2nd CCS for Straken. Gives his CCS 4x melta guns and lead from behind the blobs, not the front.

Give the blob PISs melta guns so they can shoot and assault. Give them melta bombs for walker defence. Yeah, totally ditch the Commissar and Fist in the PCSs as that is wasted points.

Give Al'Rahem a long, hard look. If you use him, do not give his platoon HWSs. I would consider SWSs or even two 20 man blobs.

Good luck!