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Ok this came up last night when i was battling a friend. I had some attack bikes within range of my sanguinary priests FNP bubble and htey got shot by a S8 weapon that had i believe AP5. So we were trying to figure out if for the double toughness negating of FNP if it checks for toughness before or after the bike modification.

You do not get FNP vs instant death.

the toughness 4 is used for instant death.

Thus, you do not get FNP vs S8 missiles.

If their stat line is like my Ork Bikers they are T 4/5. Meaning a STR8 weapon will paste one.

I think the question has been answered.

That being said - Spacewolf Weinerdog Riders are T5. That's total Codex creep crap,

The rules for Instant Death specify your *unmodified* toughness, the Bike entry even reminds you that this is the case.