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Bear in mind I'll face a lot of MEQs.

HQ - Typhus - 225

Elite
5 terminators - 4 LC - 1 CF - 1 HF - 1 Combi melta - MoT - 250

Troops
10 CSM - Champ w/ PF - Melta x 2 - Rhino - 245
8 PM - Champ w/PF - Melta x 2 - Rhino - 279
7 TS - Sorcerer with DB - Rhino - 266

HS
Obli x 3 - 225
Obli x 3 - 225
Vindicator - 125

Not sure about my HQ choice and the terminators. Maybe a chaos lord / wings in a raptor squad ?
Advice? Help? No limits on options, I have plenty in store.

HQ - Typhus is interesting and really nasty to put down. Kharn is really good for melee and quite a bit cheaper.

Terminators - I've had bad luck with them personally, but I suggest giving them all lightning claws and the mark of Slaanesh. That's 20 attacks on the charge, and you can re-roll wounds PLUS no saves for the enemy. SM terminators wouldn't stand a chance because you have +1 initiative from MOS and hit first.

Vanilla Chaos Space Marines - Meltas = great, but I'd recommend swapping the 10 with those stats for 7 PMs, the PMs will last a LOT longer.

Plague marines - My personal favorites. Meltaguns or Plasma guns will do well here. Even if the plasma "Gets Hot," feel no pain can save you.

Thousand Sons - Cool models, cool fluff, but i'd replace with Khorne Berzerkers. These guys can help to do a sweeping advance when PMs hold the lines.

Oblits - VERY useful

Vindicator - Great. You might want a Havoc Launcher on it too though.

Right, Typhus, he's only going to work in a Land Raider, or DS with a lot of Terminators (preferably other things DS as well).
If your Termies aren't in transport, or your not running a lot/a big squad I don't think their worth taking, not like that anyway. Maybe take a squad of 3-5 with Combi-plasmas and one Chainfist. Or just leave them out completely.

Daemon Prince, probably with Lash, is pretty much your best option for HQ, I know some people think there cheesy (God knows why, they're good, but there not that good) and some people might think the opposite, but I think they're a very solid option, and will work well with your Oblits/Vinid.

Drop the Plagues down to 7, and TS up to 8 (presuming its 7 & sorcerer, not 7 inc Sorcerer, so it becomes 9 overall) thats there 'sacred' numbers, not that it means anything really, but I think they are effective in those numbers. If you wanted to be 'competitive' the 'best' way to run PM is 5 of them, with 2 Metlas in a rhino.

Maybe think about some Chosen in rhino, with plasma or Melta (or a mix, that can work well).

Seb wrote:10 CSM - Champ w/ PF - Melta x 2 - Rhino - 245

An icon is worth it, as they aren't the best at h2h (considering SW & GK).

Seb wrote:8 PM - Champ w/PF - Melta x 2 - Rhino - 279

I'd add ea to this rhino.

Seb wrote:7 TS - Sorcerer with DB - Rhino - 266

With 6 oblits and a Vin's pie-plates, no Lash? Dude, go Lash.

Seb wrote:Vindicator - 125

Needs Daemonic Possession.

Seb wrote:Not sure about my HQ choice and the terminators. Maybe a chaos lord / wings in a raptor squad ?
Advice? Help? No limits on options, I have plenty in store.

The sorcerer is okay. Most Chaos Lords are poor choices given what DPs can do.

Ok, few touchups:
Regular CSM in PM
Exchanging terminators for a dread (CCW + PC one)
Lash prince instead of Typhus

Thoughts?

Put the Terminators back in. Unless you plan on running the dread up alongside a table edge far from your other troops they arent reliable IMO. If you had 2 dreads you could keep together with plasma cannons it would be a different story. All personal preference though.