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One of the tough things about that question (and the prior one) is that it's hard to talk about a normal Ork Boy or Big Mek.

Big Mek Ratchethead may be a weedy little git mostly useful to the boss for his knowledge of making stompas, while Big Mek Geargrinda may be all about fine tuning his powerklaw to better krump them marine boys. And either one might have found some fancy gubbins to put together into a gun that will tear a hole right through power armor provided they can hit the marine.

The only real constant is that Orks get bigger and tougher the more they fight (so long as they live through the fighting). For the sake of your story you could easily make the Mek a match or more than one for the marine, or weak individually but protected by a killa kan he just installed a gretchin in, or just an easily killed speed bump, or whatever else you need to make the narrative work.