They have different jobs in my opinion. Nob Bikerz hit hard, provide a healthy screen for your other units, and can rapidly react to what your opponent does. They run around and do a few different things fairly well but are not the end all, be all of their respective roles. They hit hard in Combat, but Toughness aside are a little squishy. They can shrug off enemy shooting fairly well however with their Warbikes, and their Dakkagunz mean they are actually hurting any deployed enemy infantry.
Meganobz in a Battle Wagon on the other hand just hit hard at a single point in close combat. Preferably somewhere your opponent really doesn't want several bruisers with a 2+ save and multiple wounds to be. They aren't very mobile. They'll get stuck in, and probably prevail, but once they are somewhere that's basically it. You use them to break the enemy line.
So really, it depends on what else you are doing with your Army List.
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