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When my skinks gak their poisoned shots at a bolt thrower, does the poisoned still apply? Or no because it is a machine?

Sure it works.

Unless the unit says immune to poison, has to roll normally, or they have a ward vs. poison, then it works as usual.

Think in 6th war machines werent affected by poison, but since then they are "Normal" unless stated otherwise

Also remember that poison can affect things like skeletons, steam tanks, giant animated statues, etc.

Unfortunately for us elf players poison does work as stated. Chameleon Skinks have devastated my war machines on a couple of occasions now - they scout up then march into the face of the guns to unleash a storm of poisoned shots. They only hit on a 6 but its an auto wound. A unit of 6 double shooting is statistically enough to down a HE bolt thrower.