DE characters have a wealth of AP3 options which will cut through power armor like no tomorrow in the event you get into close combat. However, a squad of tactical marines will probably outlast a unit of wyches (unless they get +1 strength for drugs) so keep that in mind.
I take a slightly different approach with my DE army compared to a traditional list. I DO blasterborn units in venoms and such but I put 3-4 grotesques with a Succubus, Archon, or character (Urien or Lilith) in a raider with aethersails. I use this unit to instantly turbo boost into my enemy ranks turn 1. It's a sacrificial unit that my opponent has to deal with, can tear through just about anything, and distracts long enough for the rest of my army to get into position and pick off other units. On that one specific raider, I tend to bring a disintegrator cannon instead of a dark lance as well, allowing it to take out terminators and other annoying units if it survives (which is rare).
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