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Space Wolves specifically?

Those rocket toting Long Fangs will kill him almost as easily as they kill any other marine.

Thing is kharn is not gonna be running around on his own he will have a squad either zerks or CSM so any squad you feed him is gonna be obliterated in a turn probably without losing a single guy with 10 albative wounds kharn will not be easy to get to with dakka you will have to focus alot of firepower to take him down leaving the rest of his army to run free