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Since I remember this being mentioned in passing as having happened in one or two smaller Dynasties in the Necron book, yes, I'd say it's entirely possible.
How's this for a scenario: The Flayer Virus gets into a several Tesseract Vaults and infects the C'tan held therein. When the Vaults are opened, the Flayer Virus has overtaken them completely, from across the galaxy. The necrodermis can't contain the flayerised C'tan shards, its not strong enough, and so they shatter, freeing the shards... and then the Shards are guided by their mutual infection and reform the obliterated C'tan that spawned said virus.
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