It's actually quite tough to deny buffs, even if you have a lot of dice.
That's because the chances of getting a 6 on your deny rolls is pretty tough. When you need to get multiple 6's, it's extraordinarily tough.
As others have mentioned, if you are trying to stop powers used against your army, you can use tricks like the khorne collars are having psykers. Changing that deny roll to either a 5+ or 4+ makes all the difference in the world.
When denying at a 6+ though, not much can be blocked.
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