I've found that in our games, it works best if either everyone is human or marine, in which case everyone is on a level playing ground so the campaign is easier to balance, have a very small number(Maybe 2 in 6 max) characters be allowed to play as marines; these guys are essentially the big guns that tower the frontline, or if there is a heavy number of people that want to play marines and others want to play exclusively humans, have the marines as special assets, so each player can make a marine but must also make a human character, each player can use their marine or human, however they must take it in turns using their marine per mission or, if the players agree, bring along the most capable marine for the situation they expect (Eg, Gladiatorial coliseum for a daemon artefact? bring the Khornate zerker, night raid? Bring the Night lord.)
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