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Yes, always in a well-ventilated area, regardless of what you are spraying. Only water-based inks are somewhat safe, but still the tiny atomized particles are not doing you any good.
If you have to paint inside, just avoid the high VOC paints and a simple air mask will filter out the particulate matter that is harmful. If spraying high VOC paints (lacquers, enamels, etc.) then you do need a respirator to block the fumes as well as the particulates.
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