Having the Mark of Nurgle simply opens you up to buffs, such as Icons, Psychic Powers, and some character-specific buffs.
A nurgle CSM force is a close-range force, but not melee; Plague Marines do have a fancy selection of melee weapons but aside from +1 attack from Vectors of Death and Disease, they don't really have much else buffing their melee capabilities (whereas Khorne berserkers....yeah). Even Poxwalkers, who have no guns, are better off being used as tarpits and meatshields than frontline assault units (although if you meet something they can actually easily kill, like guard infantry, by all means charge in; they will start making back their numbers in short order). The thing is Plague marine guns are extremely close range, so you are almost certainly going to get charged. those weapons will help to survive that charge; your guns should have taken out a good chunk of the opponent and your choppy bitz should either deter them or be able to finish them off.
The main perk of Poxwalkers is that they don't flee; they make great bubblewrap because you don't need something else to babysit them to make sure they don't run from a bad morale check. Typhus buffing them is just the icing on the cake; since they don't break and run, you'll have to go through all of them and making them even harder to kill just exacerbates your opponent's frustration.
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