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2012/08/09 20:04:28
Subject: Ghonorrhea growing resistant to only drug left to treat it
May the the blessings of His Grace the Emperor tumble down upon you like a golden fog. (Only a VERY select few will get this reference. And it's not from 40k. )
2012/08/15 20:36:25
Subject: Ghonorrhea growing resistant to only drug left to treat it
Relapse wrote:It might get to the stage where people saying abstnence is best won't be so lightly dismissed.
Historically, this was a big driver for monogamy when the first big STDs rolled through Europe.
-"Wait a minute.....who is that Frazz is talking to in the gallery? Hmmm something is going on here.....Oh.... it seems there is some dispute over video taping of some sort......Frazz is really upset now..........wait a minute......whats he go there.......is it? Can it be?....Frazz has just unleashed his hidden weiner dog from his mini bag, while quoting shakespeares "Let slip the dogs the war!!" GG
-"Don't mind Frazzled. He's just Dakka's crazy old dude locked in the attic. He's harmless. Mostly."
-TBone the Magnificent 1999-2014, Long Live the King!
2012/08/15 22:25:24
Subject: Ghonorrhea growing resistant to only drug left to treat it
Only if you have unprotected sex with people you dont really know.
There's a lot of people that catch it from someone they know who had a swingin' time with strangers. To tell the truth, if I wasn't sure if someone had the clap or not, I wouldn't be too keen on a lil' piece of rubber that's known to break being all that stood between me and some disease that would permanently wreck my body.
This message was edited 1 time. Last update was at 2012/08/16 01:57:14
2012/08/17 18:32:20
Subject: Re:Ghonorrhea growing resistant to only drug left to treat it
The problem also stems that it's REALLY hard to determine what bug is affecting you in a timely manner... so, your doctor may give you a FULL SPECTRUM of anti-viral/anti-biotic right away, while sending culture samples to the lab. It may take several hours to a couple of days for the culture to grow and be identified.
What this does is that it exposes the bugs and they inherently can develop resistent strains.
I’ve had the opportunity to learn more about antibacterial drug discovery in the last year or so – that was one of the few therapeutic areas I hadn’t worked in, actually. And although I already knew that it was no picnic in the park (I’d heard the complaints), doing it myself has given me a new respect for the nasty resilience of bacteria.
I’ve been used to having my compounds go into cell assays, where a good number of them fail. That’s expected – every medicinal chemist knows that some of the potent compounds in the primary assay (against the purified protein target) are going to wipe out when they go up against cells. Cells have membranes, for one thing, and they have bailing pumps built into them to spit out molecules that they don’t recognize. I’ve seen compounds, as has everyone who does drug discovery, that bounce right off the cell assay while closely related analogs work just fine. That’s why you run the assay, to weed those guys out – you may not every understand what specifically went wrong, but you at least get a chance to try to avoid it as you go on.
But bacteria are different beasts. Their independent, free-living nature makes them nastier than even tumor cell lines. Cancer cells, aggressive creatures though they are, still expect to get their food delivered (and their garbage hauled) by the bloodstream. (That’s what makes angiogenesis a drug target in oncology). But bacteria have to search out their own meals, fighting it out with every other bacterium in the area while doing so. Their membranes are like armor plate compared to a lot of higher-organism cell lines, with the gram-negative organisms taking the trophy. Or is it the mycobacteria? (They're both awful, and the proportion of compounds that fail when you move past the pure-protein stage is thus far higher). They react to threats, communicate with each other, and reproduce like crazy. It’s like dealing with a swarm of tiny, self-replicating attack submarines.
So yes, finding an effective new antibacterial drug is a real triumph, and it’s not a triumph that’s been happening very often in recent years. This gets mentioned a lot in the popular press, when they feel like running a Coming of the Superbugs piece, and one of the usual explanations is that drug companies got out of the area years ago because they thought the problem wasn’t big enough to worry about. That’s part of the explanation – or was, quite a while ago. And the finances are different in this space, true. You’re never going to have a multibillion dollar blockbuster, because a new agent is going to be reserved just for infections that are unresponsive to the older drugs. But it’ll still sell.
No, there are plenty of companies working in the area now, and many that never left. And the need for new agents is clear, and has been for quite a while now. The real reason that we don’t have lots of new antibacterial drugs is that it’s really hard to find them, for one thing, and the the bacterial are more than capable of fighting back when we try.
This message was edited 1 time. Last update was at 2012/08/17 18:45:51
Live Ork, Be Ork. or D'Ork!
2012/08/17 18:41:34
Subject: Ghonorrhea growing resistant to only drug left to treat it
If people would just cling to Jesus and only have sex with they are married to and no one before or after this wouldn't be an issue.
Jesus is the ultimate anti-biotic.
Bwahahahaha, JK
Avatar 720 wrote: You see, to Auston, everyone is a Death Star; there's only one way you can take it and that's through a small gap at the back.
Powder Burns wrote:what they need to make is a fullsize leatherman, like 14" long folded, with a bone saw, notches for bowstring, signaling flare, electrical hand crank generator, bolt cutters..
2012/08/17 18:45:28
Subject: Ghonorrhea growing resistant to only drug left to treat it
AustonT wrote:If people would just cling to Jesus and only have sex with they are married to and no one before or after this wouldn't be an issue.
Jesus is the ultimate anti-biotic.
Bwahahahaha, JK
I thought it was aspirin?!?! ya, know, the kind you put it between your knees and hold it?
Live Ork, Be Ork. or D'Ork!
2012/08/19 00:13:08
Subject: Ghonorrhea growing resistant to only drug left to treat it
The centre of a massive brood chamber, heaving and pulsating.
Clinging to Jesus...Isn't he dead? Isn't that necrophilia?
Oh the temptation to make a "Christ's Second Coming" joke.
Squigsquasher, resident ban magnet, White Knight, and general fethwit.
buddha wrote: I've decided that these GW is dead/dying threads that pop up every-week must be followers and cultists of nurgle perpetuating the need for decay. I therefore declare that that such threads are heresy and subject to exterminatus. So says the Inquisition!
2012/08/19 01:34:20
Subject: Ghonorrhea growing resistant to only drug left to treat it
This message was edited 1 time. Last update was at 2012/08/19 01:38:57
Proud Member of the Infidels of OIF/OEF
No longer defending the US Military or US Gov't. Just going to ""**feed into your fears**"" with Duffel Blog Did not fight my way up on top the food chain to become a Vegan...
Warning: Stupid Allergy
Once you pull the pin, Mr. Grenade is no longer your friend
DE 6700
Harlequin 2500
RIP Muhammad Ali.
Jihadin, Scorched Earth 791. Leader of the Pork Eating Crusader. Alpha
2012/08/19 02:29:03
Subject: Ghonorrhea growing resistant to only drug left to treat it
It's not helped by the fact that Gonorrhea treatments aren't a field with high profit margins, so almost no major pharmaceutical is working on this. Once again capitalism proves that it's there to react to crisis, not prevent it.
----------------
Do you remember that time that thing happened?
This is a bad thread and you should all feel bad
2012/08/19 03:45:57
Subject: Ghonorrhea growing resistant to only drug left to treat it
whembly wrote: The problem also stems that it's REALLY hard to determine what bug is affecting you in a timely manner... so, your doctor may give you a FULL SPECTRUM of anti-viral/anti-biotic right away, while sending culture samples to the lab. It may take several hours to a couple of days for the culture to grow and be identified.
What this does is that it exposes the bugs and they inherently can develop resistent strains.
It takes 24-48 hours for N.gonorrhoeae to grow via conventional methods and a further 24-48 hours to get a confirmed ID and sensitivity pattern. Thats broadly the same as other pathogenic bacteria but there are methods which will given an ID in a much shorter timeframe
Doctors irresponsibly perscribing antimicrobials is a leading cause of drug resistance and any doctor who does give you a broad spectrum antimicrobial without having lab results in most cuircumstances is effectively negligent.
N.gonorrhoeae is usually susceptable to spectinomycin but it isn't licensed in the US so there options left for the rest of the world
Absintence has never worked so its not something that I would advocate, even if I was inclined to.
This message was edited 3 times. Last update was at 2012/08/19 09:18:29
RegalPhantom wrote: If your fluff doesn't fit, change your fluff until it does
The prefect example of someone missing the point.
Do not underestimate the Squats. They survived for millenia cut off from the Imperium and assailed on all sides. Their determination and resilience is an example to us all.
-Leman Russ, Meditations on Imperial Command book XVI (AKA the RT era White Dwarf Commpendium).
Its just a shame that they couldn't fight off Andy Chambers.
Warzone Plog
2012/08/19 13:59:25
Subject: Re:Ghonorrhea growing resistant to only drug left to treat it
whembly wrote: The problem also stems that it's REALLY hard to determine what bug is affecting you in a timely manner... so, your doctor may give you a FULL SPECTRUM of anti-viral/anti-biotic right away, while sending culture samples to the lab. It may take several hours to a couple of days for the culture to grow and be identified.
What this does is that it exposes the bugs and they inherently can develop resistent strains.
It takes 24-48 hours for N.gonorrhoeae to grow via conventional methods and a further 24-48 hours to get a confirmed ID and sensitivity pattern. Thats broadly the same as other pathogenic bacteria but there are methods which will given an ID in a much shorter timeframe
Doctors irresponsibly perscribing antimicrobials is a leading cause of drug resistance and any doctor who does give you a broad spectrum antimicrobial without having lab results in most cuircumstances is effectively negligent.
N.gonorrhoeae is usually susceptable to spectinomycin but it isn't licensed in the US so there options left for the rest of the world
Absintence has never worked so its not something that I would advocate, even if I was inclined to.
It might come down to the fact that abstinence is going to be the only thing there is as an answer to STD's if drugs no longer work. I've seen people that have had to live with the results of syphillis that went untreated. It's something that makes abstinence suddenly entirely an option.
Automatically Appended Next Post: The facts on Herpes, never minding Ghonorrhea are enough to give a thinking person pause.
That's why STD's are so prevelant. The education is there, but people don't seem to care.
Most casual sex is the result of alcohol and people tend to think that 'it won't happen to me'. (Nearly) everyone in the western world knows that using a condom is a really good idea yet somehow STIs are still prevalent. I think that tells you all you need to know at how effective abstinence would be.
Scare stories about 'untreatable' STIs and unreliable prophylactic measures really don't help.
RegalPhantom wrote: If your fluff doesn't fit, change your fluff until it does
The prefect example of someone missing the point.
Do not underestimate the Squats. They survived for millenia cut off from the Imperium and assailed on all sides. Their determination and resilience is an example to us all.
-Leman Russ, Meditations on Imperial Command book XVI (AKA the RT era White Dwarf Commpendium).
Its just a shame that they couldn't fight off Andy Chambers.
Warzone Plog
2012/08/20 11:59:24
Subject: Re:Ghonorrhea growing resistant to only drug left to treat it
That's why STD's are so prevelant. The education is there, but people don't seem to care.
Most casual sex is the result of alcohol and people tend to think that 'it won't happen to me'. (Nearly) everyone in the western world knows that using a condom is a really good idea yet somehow STIs are still prevalent. I think that tells you all you need to know at how effective abstinence would be.
Scare stories about 'untreatable' STIs and unreliable prophylactic measures really don't help.
I've never met anyone who cought the clap from not having sex with an infected person.
2012/08/20 14:28:57
Subject: Ghonorrhea growing resistant to only drug left to treat it
Powder Burns wrote:what they need to make is a fullsize leatherman, like 14" long folded, with a bone saw, notches for bowstring, signaling flare, electrical hand crank generator, bolt cutters..
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