Probably not. Because Nukes, sadly, are the kind of "that needs actual skill to manufacture" technology that would be reserved by the Mechanicus. Certainly compact weapons, anyway.
Nukes are a weapon recognised in the 41st millenium, by the way; they're mentioned in a few places - the Princeps of the Imperius Dictatio (mis)identifies a massive detonation and mushroom cloud as a nuclear detonation.
They're just disliked as a weapon by the Imperium because of nuclear contamination; even the most unpleasant conventional battle will still leave the world useable again within a decade or so; whilst massed use of nukes is a long-term problem. It's the same logic as "send in 1,000,000 more guardsmen to certain death" being a better long term plan than "exterminatus from orbit".
If space marines were really "movie marines", I'd just waste them with nukes.
The problem is actually targeting them. Marines are ludicrously fast in tactical mobility (in most 'real case' battlefield scenarios, you see them enter either by orbital drop, teleport, or gunship) and (unlike a board game) tend not to engage in fair fights.
But 'nuke it' is definitely a thing. Steve Jackson discussed the 'Ogre Limit' (named for an old board game) in a gaming article years ago - the maximum size at which you can viably build a war engine, because anything bigger is worth using strategic weapons (like nukes and orbital gunfire) on.
Quite a lot of
40k war engines are well the wrong side of this line.....
In practice, yes, the only Destroyer weapon the Imperial Guard have native access to is the Volcano Cannon of the Shadowsword, or Turbolasers/Volcano Cannons on attached Titans.
