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If it'sjust removing a crust of old paint, Master's and patience will do the trick. If the bristles have been kinked and splay badly, though, it's likely beyond help - trash it or remove the crust and relegate it to drybrush/glue spreading/paint transfer duty. I'd avoid harsh solvents like turpentine if it's a natural hair brush, but feel free to use it and its ilk on synthetics - never used Simple Green on a brush, so I'm not sure what it would do to the bristles. It will loosen the paint, at least, but I know that I can do it with Master's without risking irreparable damage.
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