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They could have stacked the deck a little more against the Emperor for the final battle with Horus. The entire plan was contingent on Horus having an heroic BSOD though, which is a bit of a gamble.
I'm a little dubious about Horus exterminating the human race entirely though; humanity just doesn't have the genocidal thoroughness of the Necrons or Tyranids.
The most likely "finish" for humanity in this situation would be Horus dealing extreme damage, and then the Eldar stepping in to mop up the rest.
(Aside, in fact the Cabal's plan makes a lot more sense if you think of it as a plot by some extremist Eldar to use Chaos to destroy humanity, leaving the stage clear for the Eldar to reclaim their galaxy. Not all Eldar agree with the idea though because Chaos is so dangerous, and this is why Eldrad steps in to try and stop the "Cabal".)
If it had somehow been successful and humanity was completely eliminated then it is possible that some other xenos race may have risen to prominence. The Tau? Something similar? We just don't know.
In all probability the galaxy would have been filled with a million small-scale wars between xenos races trying to expand... until the Tyranids arrive.
The Silent King may have had more success awakening the Necrons with no major opponents to stop him, so there may well have been a galaxy-wide slugfest between the Tyranids and Necrons. or the Necrons may have just slept through the whole thing and hoped that the next alarm clock brought them more luck.
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