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Well Wyches are best against your opponants CC specialists as they negate having two weapons, they negate having power weapons (inv save), They half the weapon skill of incoming attacks so are usually only hit on a 4+ negating a high weapon skill, and strike at a ridiculus I negating high I.
They also have combat drugs where every result is good/decent.
Most of the damage is done by the succubus with his/her agoniser.
Where they are not as effective is engaging basic troops as they care not for most of their neutering effects. If you catch my drift.