In my limited experince, a 'good' use of locks are when the opponent would first have to move the model to engage, this is because breaking a lock happens during the attack portion of the models activation, ergo they must forfeit that turns movement.
Examples:
1. Locking from behind a model. Even if the lockee breaks the hold they will be unable to turn and face the locker, eliminating the fear of focus/fury fueled counter attacks.
2. Locking at reach. This is a gargossal only perk, as they can use their natural reach on power attacks to lock a model without reach. Again, even if the model breaks the hold they would be unable to retaliate.
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