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I think the average would be between tolerated and killed. Most worlds where life is a physical struggle (savage / death worlds) wouldn't bother as the chance of them surviving would be very low. On hives they would probably just be thrown into one of the lowest possible jobs and left there.

It depends on what the lifestyle is and how crippling the disability. If they can function they would probably get the same treatment as everyone else. If they can't work they would have to be provided for by their family or left to die.

The imperium isn't very keen on helping people who can't contribute. Human life is cheap- while medicine is advanced it's also very expensive.