In a development that could change the way the deadly Ebola disease is fought, researchers have announced promising results of a new vaccine's trial in Guinea, one of several countries affected by a historic outbreak in West Africa.

"The estimated vaccine efficacy was 100 percent," a team of researchers say.

The trial was called Ebola ça Suffit – French for "Ebola that's enough." Funded by the World Health Organization and other groups, it started in April and ended on July 20, relying on participants who consented to be part of the trial. The more than 20 researchers who took part published their findings in The Lancet medical journal Friday.

"The current data basically tells us that the vaccine works to protect people against Ebola," says Dr Bertrand Draguez, medical director of Médecins Sans Frontières, which took part in the research along with WHO and authorities in Guinea.

Draguez and other experts are heartened by the new results — but they also warn that as testing expands, the effectiveness rate of the vaccine will likely fall below 100 percent. The trial used the "ring vaccination" method, in which all suspected contacts receive treatment. No placebos were administered.

"Even if the sample size is quite small and more research and analysis is needed," Draguez says, "the enormity of the public health emergency should lead us to continue using this vaccine right now to protect those who might get exposed to the disease: contacts of infected patients and frontline workers."

The trial vaccine, formally called rVSV-ZEBOV but more commonly known as VSV-EBOV, was supplied by the pharmaceutical firm Merck Sharp & Dohme. The drug was initially developed by Canada's Public Health Agency and was tested as early as 2011.

To conduct the Guinea trial, researchers used newly confirmed Ebola cases to identify clusters of people with whom the patients had contact. On a random basis, those clusters then either received the vaccine immediately, or after a 21-day delay.

"In the immediate vaccination group, there were no cases of Ebola virus disease with symptom onset at least 10 days after randomization," the researchers say, "whereas in the delayed vaccination group there were 16 cases of Ebola virus disease from seven clusters, showing a vaccine efficacy of 100 percent."

Researchers say that for both groups — those who got the vaccine immediately and those who received it after a delay — no new Ebola cases were diagnosed starting at six 6 days after vaccination.

The randomization phase of the trial was stopped this week, WHO says, "to allow for all people at risk to receive the vaccine immediately." It will also now include younger people than the adults involved in the trial.
Mohamed Soumah, 27, was the first person to be vaccinated in the Ebola vaccine trial. "I was afraid," he says. "People in the village were saying that the injection was to kill me."

Mohamed Soumah, 27, was the first person to be vaccinated in the Ebola vaccine trial. "I was afraid," he says. "People in the village were saying that the injection was to kill me."
Sean Hawkey/Sean Hawkey

The first person to receive the trial vaccine in Guinea was Mohamed Soumah, 27. He tells WHO:

"It wasn't easy. People in the village said that the injection was to kill me. I was afraid. I was the first one to be injected, the very first, here in my village on 23 March 2015. I've been monitored for 3 months and I've had no problems. The last follow-up, 84 days after the vaccination, was all clear."

The vaccine is administered via a shot to the upper arm. The researchers who ran the trial say their results suggest that a single injection is highly effective, and that protection against Ebola can be established quickly. They're also still analyzing possible adverse reactions to the drug.

The interim findings on the Guinea trial are the latest to bolster the belief that VSV-EBOV could be the drug Ebola-fighters have been waiting for. Earlier this year, it showed positive results in clinical trials at the Walter Reed Army Institute of Research and the National Institute of Allergy and Infectious Diseases.

A Walter Reed release about that study explained how the drug is derived:

"VSV-EBOV is based in part on a genetically engineered version of vesicular stomatitis virus, which primarily affects rodents, cattle, swine and horses. Human VSV infections are rare and mild. In the VSV-EBOV investigational vaccine, the gene for the outer protein of VSV replaces the same gene segment of the Zaire Ebola virus species."

Researchers in the Guinea trial say that the number of new clusters of potential patients is falling, because the rate of new diagnoses in the country has dropped. The next immediate step, they say, is to continue the trial and vaccinate more people. Last Friday, Guinea's government and medical ethics groups approved that plan.

Anonymous person with a tin foil hat on wrote: But vaccines cause autism! something something big pharma!

 gorgon wrote:
I eagerly await the arrival of the usual suspects from the last Ebola thread, so that they may explain to us how *THIS* means the end of all of us.

 Daemonhammer wrote:

Anonymous person with a tin foil hat on wrote: But vaccines cause autism! something something big pharma!

 Desubot wrote:
That's enough Ebola

 KaptinBadrukk wrote:
Um...I mean, that's great news, but will it be affordable in poor, ebola infested countries?

 ScootyPuffJunior wrote:
Quick, some call Peter Wiggin and let him know he can come out of hiding after the Ebola scare last year!

 Jimsolo wrote:

 KaptinBadrukk wrote:
Um...I mean, that's great news, but will it be affordable in poor, ebola infested countries?

It's a scary enough one that I think we can count on countries/foundations/dudes with deep pockets and guilty consciences to do most of the heavy lifting on that front.

Ouze wrote:

 ScootyPuffJunior wrote:
Quick, some call Peter Wiggin and let him know he can come out of hiding after the Ebola scare last year!

That thread.

Just good clean fun

 d-usa wrote:

Ouze wrote:

 ScootyPuffJunior wrote:
Quick, some call Peter Wiggin and let him know he can come out of hiding after the Ebola scare last year!

That thread.

Just good clean fun

I'm kinda sad that the vaccine news preempted your "let's revisit this in a year" picture.

 Ensis Ferrae wrote:
Frazz... you do realize it's only Thursday, right???

 Avatar 720 wrote:

 Ensis Ferrae wrote:
Frazz... you do realize it's only Thursday, right???

Just so you know, this thread was created on the 31st of July, which was actually a Friday.

 Frazzled wrote:

 Avatar 720 wrote:

 Ensis Ferrae wrote:
Frazz... you do realize it's only Thursday, right???

Just so you know, this thread was created on the 31st of July, which was actually a Friday.

In your face Don Quixote! And its Friday now. I know because I am wearing a bright red hawaiian shirt with pictures of Santa surfing...like a Boss.