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From personal experience from being on the receiving end of one, a daemon prince of Khorne with wings and axe of Blind Fury has been really brutal when charging my units.

However, I've learnt to just shoot it off the table before it can do anything. If it was me personally, I would run with a daemon prince with mark of Nurgle, wings and psychic powers. Not sure about melee weapon though. Nurgle seems to be one of the better marks for Chaos Space Marines.