My experience is that too much water can cause that to happen. If you go over the spots with “full strength” wash, it should dissolve the deposits (might take a gentle wiggle of the brush) and reincorporate the pigment.
I had something similar happen with Reikland Fleshshade when I watered it down too much.
PS: make sure you shake it really well. There shouldn’t be any sediment on the bottom.
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