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Is it possible for a psyker to lose his powers for good (either accidentally or willingly)? If yes, how?

Yes, in a short story a powerful psyker in service to the inquisition over taxed her power to save her life and that of her inquisitor superior, but was severely injured in the process. She lost her psychic powers and was stuck in an hospital bed for the rest of her life.

I've seen references to psykerdom and blankness being genetic, I don't think you could lose either without being killed or somehow seriously crippled.

Path of the Seer mentioned how an Eldar can be stripped of their power as punishment.

I would say that they can't lose their power by natural means, but other ultra-powerful subjects (Ahriman, Eldred etc) might be able to strip away their powers somehow.
Its an interesting question, I want more answers for this.

epronovost wrote:
Yes, in a short story a powerful psyker in service to the inquisition over taxed her power to save her life and that of her inquisitor superior, but was severely injured in the process. She lost her psychic powers and was stuck in an hospital bed for the rest of her life.

which story?

There's a situation in Ravenor where a blank gets "withered down" by chaos to the point of being succeptible to telepathy.

Psykers "should" not be able to lose their powers, though a lobotomy or servitor process might do the trick.

In the novel "The outcast dead" a thousand sons pysker is able to destroy his own powers.

pm713 wrote:
Path of the Seer mentioned how an Eldar can be stripped of their power as punishment.

And for an Eldar this is far worse that just having some extra power removed. Since all Eldar are psychic to a small degree and use that ability to communicate with other Eldar, having their psychic ability removed is also like rendering them deaf and mute for the rest of their lives.
Hence why it is a severe punishment in Eldar society.

 Galef wrote:

pm713 wrote:
Path of the Seer mentioned how an Eldar can be stripped of their power as punishment.

And for an Eldar this is far worse that just having some extra power removed. Since all Eldar are psychic to a small degree and use that ability to communicate with other Eldar, having their psychic ability removed is also like rendering them deaf and mute for the rest of their lives.
Hence why it is a severe punishment in Eldar society.

Excellent insight.

There was a discussion similar to this over on The Dark City about Dark Eldar and empathy, and it's my opinion that by letting their psychic powers wither the Dark Eldar have a much lower capacity to feel empathy for other beings.

Imaging being able to reach out and connect directly with another being's mind. That would be a profound basis for your species to develop a sense of empathy. Stripping that away would be like for us to completely replace face-to-face interaction with texting/magic-text bots*. How do you know that whatever's talking on the other end is a person like you?

*He says while being completely aware of what he's doing at the moment...

Anyway, apologies for the potential threadjack...

Outcast dead.

The 1000 son loses power to a anti psy assasin.

Kills enemy, destroys power doing it.

If they have enough wounds and keep rolling the right result on the perils table, certainly.