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 reds8n wrote:
"UK secures deal for 90 million COVID-19 vaccine doses

The UK has become the first country to sign a deal with a number of pharmaceutical companies for early access to COVID-19 vaccines. The first is with BioNTech and Pfizer, for 30 million doses. The second deal, for 60 million doses, is with French firm Valneva. These are in addition to the 100 million doses of the Oxford University vaccine being developed by AstraZeneca"

It makes sense - they have to start manufacturing them so that once approved they can be distributed immediately. By buying some of each they're increasing the chances that they will have at least one effective vaccine.

There have also been some really good developments on drugs to help reduce symptoms and either keep people off of ventilators, or help them recover more quickly once they are on them (freeing them up for other patients).

 RiTides wrote:

 reds8n wrote:
"UK secures deal for 90 million COVID-19 vaccine doses

The UK has become the first country to sign a deal with a number of pharmaceutical companies for early access to COVID-19 vaccines. The first is with BioNTech and Pfizer, for 30 million doses. The second deal, for 60 million doses, is with French firm Valneva. These are in addition to the 100 million doses of the Oxford University vaccine being developed by AstraZeneca"

It makes sense - they have to start manufacturing them so that once approved they can be distributed immediately. By buying some of each they're increasing the chances that they will have at least one effective vaccine.

There have also been some really good developments on drugs to help reduce symptoms and either keep people off of ventilators, or help them recover more quickly once they are on them (freeing them up for other patients).

People grossly underestimate the manufacturing and distribution challenges we're going to have after one or more of these vax candidates are approved.

 hotsauceman1 wrote:
Movie theaters are the worst. You go in, spend like, 29-30$ to see a movie in a crowded room full of strangers who never stay quiet and laugh so hard I miss parts of the movie. if you gotta pee you miss parts of the movie.
Where movie can be release direct to my house, they have no purpose anymore. They only exist to justify hollywoods giant overinflated budget CGI driven mess.
Trolls 2 and Onward did amazing with VOD, lets follow their lead.

Well i know my home has nowhere near enough room for such a screen and neighbours would be complaining about noice with such audio output. And dubious my home could be fitted with equally good output.


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Oxford vaccine is showing increase in resistance to virus though how lasting is next step. Fairly safe though 70% receivers gets fever or headache but treatable level with standard medicines

Gorgon - Oh absolutely! But the first step is to pay up and get the manufacturing rolling... how they figure out everything downstream of that is going to be pretty crazy.

tneva82 wrote:

Oxford vaccine is showing increase in resistance to virus though how lasting is next step. Fairly safe though 70% receivers gets fever or headache but treatable level with standard medicines

I'd take those side effects in a heartbeat if a vaccine gave resistance.

I can relate to this woman’s story.

https://www.washingtonpost.com/nation/2020/07/18/covid-pandemic-store-clerk-north-carolina/?arc404=true

Pandabeer wrote:
You are really oversimplifying schools' role in kids' lives. A year of not being able to attend school properly means wasting a year of the childs' time during which the brain can learn new things at (comparatively) breakneck speed. This speed rapidly declines as the child comes closer to adulthood where it settles at a much slower pace. Ever wondered why every child that doesn't have a mental handicap learns to speak it's native language fluently while picking up a new language at age 30 is very hard for even the most gifted of people? That's the reason. Wasting a year of this time means irrepairably damaging the childs' development having lifelong consequences on wellbeing, job prospects etc.

Hasn't that theory been debunked a few years ago? The last I read about especially this language learning example was that the big difference is that kids have nothing to do while 30 year old adults have jobs and responsibilities. For the most part they just don't have the time to immerse themselves into a language like kids can. People who start learning a new language at college age and who have time for that— like when taking language related courses (interpreter,…) full time—seem to learn faster than kids because they can dedicate themselves to their studies.

 gorgon wrote:

 RiTides wrote:

 reds8n wrote:
"UK secures deal for 90 million COVID-19 vaccine doses

The UK has become the first country to sign a deal with a number of pharmaceutical companies for early access to COVID-19 vaccines. The first is with BioNTech and Pfizer, for 30 million doses. The second deal, for 60 million doses, is with French firm Valneva. These are in addition to the 100 million doses of the Oxford University vaccine being developed by AstraZeneca"

It makes sense - they have to start manufacturing them so that once approved they can be distributed immediately. By buying some of each they're increasing the chances that they will have at least one effective vaccine.

There have also been some really good developments on drugs to help reduce symptoms and either keep people off of ventilators, or help them recover more quickly once they are on them (freeing them up for other patients).

People grossly underestimate the manufacturing and distribution challenges we're going to have after one or more of these vax candidates are approved.

Yep. Especially in the US. Most of 'our' pharmaceutical manufacturing is actually overseas- I'm personally envious of Germany and Switzerland on this score.

Of course, once it starts rolling, there's going to be prioritization and availability issues. It also doesn't help that politicians and journalists have been hopelessly optimistic on the arrival of a viable candidate, and don't seem to grasp that manufacturing meaningful quantities, let alone shifting those quantities to distribution centers and then to local areas are all going to take time.

I highly doubt that regarding language lol. Just personally speaking, I failed miserably at learning a foreign language later in life, while my kid was quite easily fluent in both english and spanish at just 3 years old.

There's a reason that - outside of pandemic conditions - there's a huge push to get kids better access to preschools, for instance. They can learn and absorb a crazy amount at a young age, and under normal circumstances, you want to take full advantage of that.

I think we need to be honest about the challenges kids will face, and not try to minimize those challenges by saying lost learning will be easily able to be made up later. The hard choices we're needing to make now are due solely to the severity of the consequences - NOT because kids don't learn all that well at a young age, or that schooling isn't really all that important, or any other similar minimizing argument...

If it wasnt a life or death case for many people i would agree.
But.....im not sure with the numbers we have, we can justify opening schools in all reality.
I get it can cause problems, but IME, kids can be pretty flexible.
I think we need to seriously consider that its possible this whole school year could be distance learning and prepare accordingly both as educators and those with kids on how to mitigate this.

So what I’m hearing is that it would be a wasted opportunity *not* to bust out the Klingon Dictionary for the kiddo. Qapla’!

Voss wrote:

 gorgon wrote:

 RiTides wrote:

 reds8n wrote:
"UK secures deal for 90 million COVID-19 vaccine doses

The UK has become the first country to sign a deal with a number of pharmaceutical companies for early access to COVID-19 vaccines. The first is with BioNTech and Pfizer, for 30 million doses. The second deal, for 60 million doses, is with French firm Valneva. These are in addition to the 100 million doses of the Oxford University vaccine being developed by AstraZeneca"

It makes sense - they have to start manufacturing them so that once approved they can be distributed immediately. By buying some of each they're increasing the chances that they will have at least one effective vaccine.

There have also been some really good developments on drugs to help reduce symptoms and either keep people off of ventilators, or help them recover more quickly once they are on them (freeing them up for other patients).

People grossly underestimate the manufacturing and distribution challenges we're going to have after one or more of these vax candidates are approved.

Yep. Especially in the US. Most of 'our' pharmaceutical manufacturing is actually overseas- I'm personally envious of Germany and Switzerland on this score.

Of course, once it starts rolling, there's going to be prioritization and availability issues. It also doesn't help that politicians and journalists have been hopelessly optimistic on the arrival of a viable candidate, and don't seem to grasp that manufacturing meaningful quantities, let alone shifting those quantities to distribution centers and then to local areas are all going to take time.

Erm, the manufacturing is all over the shop depending on how easily it is to outsource , the most major* production facilities to my knowledge from Novartis are in the USA, aswell as eastern europe.


Edit* major, by their own Standards truth is as soon as China stopped delievering gak went south.

Eh. Even the most optimistic figures suggest the US produces only about a quarter of its demand for pharma domestically.

No one is making big noises about ramping up facilities in anticipation for the political or public good will points, so I don't see that changing. (and Johnson and Johnson, our largest pharma company, absolutely would, as they're coming off a PR debacle with tainted baby powder)
~330 million doses of a vaccine when less than a quarter of production is domestic (and production for other drugs needs to continue)... that's going to take a while.

Imo , just an opinion, but production facilities of medical baseline products Like masks, generika , well known medicin not requireing special individualisation should've been decentralised a Long time ago
We saw what happened when the plandemic hit first and Basically all of Europe had no masks because everyone bought from China...

The problem is decentralising costs and when the pandemic ends the demand will reduce which means less market pressure. With less pressure the prices will likely settle and lower and there just won't be the need nor demand for extensive local infrastructure.

Especially when things like faceshields and masks can be more cheaply bought from overseas and then stockpiled.

One issue about vaccines is that less effective it is, the more people who need to take them for artificial herd immunity. (Not to be confused with natural herd immunity, which means exposure to the virus itself.) Of course, individual immunity is a different matter.

***

Moderna coronavirus vaccine shows 'promising' safety and immune response results in published Phase 1 study, but more research is needed
https://www.wxyz.com/news/coronavirus/moderna-coronavirus-vaccine-shows-promising-safety-and-immune-response-results-in-published-phase-1-study-but-more-research-is-needed

Oxford coronavirus vaccine spurs immune responses, appears safe on first look
https://www.biopharmadive.com/news/coronavirus-vaccine-astrazeneca-oxford-trial-results/581905/

***

COVID-19 Vaccine Will Probably Require Two Doses (June)
https://www.webmd.com/lung/news/20200605/covid-19-vaccine-will-probably-require-two-doses

fyi, Natural immunity from an infection only lasts months. If your parents remember chickenpox parties (: the first article says "COVID-19 is 100 times deadlier than the chickenpox."
https://www.mic.com/p/immunity-to-covid-19-might-last-only-a-few-months-according-to-new-research-29198226
https://www.westernmassnews.com/news/study-natural-immunity-to-covid-19-may-only-last-up-to-one-month/article_2d8fbb12-c87a-11ea-bf6a-d33cd75b2541.html


***

This new study shows how well a coronavirus vaccine must work before we can stop social distancing

"Based on these findings, a vaccine with an efficacy as low as 60% could still stop the pandemic and allow society to return to normal. However, most if not all of the population would have to be vaccinated. his seems unlikely, given polls showing that only about three-quarters of Americans say they would get a coronavirus vaccine if assured that it was safe. With fewer people protected, a vaccine would have to have an efficacy of at least 80% to be able to stop the pandemic by itself, meaning social distancing could be completely relaxed."

https://www.marketwatch.com/story/this-new-study-shows-how-well-a-coronavirus-vaccine-must-work-before-we-can-stop-social-distancing-2020-07-15?mod=home-page

***

Nasal vaccines are expected to take longer to develop, but promise to be more effective -- and obviously less invasive.
https://www.dnaindia.com/health/report-covid-19-researchers-working-on-nasal-vaccine-say-nose-sprays-may-work-better-than-injection-shots-2833157
https://indianexpress.com/article/explained/nasal-coronavirus-covid-19-vaccine-coroflu-adcovid-intravacc-6507431/

 Overread wrote:
The problem is decentralising costs and when the pandemic ends the demand will reduce which means less market pressure. With less pressure the prices will likely settle and lower and there just won't be the need nor demand for extensive local infrastructure.

Especially when things like faceshields and masks can be more cheaply bought from overseas and then stockpiled.

Sure , so what, states and governments have wasted money on worse things, Like italy and traintracks without the rails.
Or Briefes f.e.
Atleast that way you could instigate some development in poorer regions.

Not Online!!! wrote:

 Overread wrote:
The problem is decentralising costs and when the pandemic ends the demand will reduce which means less market pressure. With less pressure the prices will likely settle and lower and there just won't be the need nor demand for extensive local infrastructure.

Especially when things like faceshields and masks can be more cheaply bought from overseas and then stockpiled.

Sure , so what, states and governments have wasted money on worse things, Like italy and traintracks without the rails.
Or Briefes f.e.
Atleast that way you could instigate some development in poorer regions.

True but at the same time don't forget there's going to be a lagtime.
Post Corona the first order will be getting current companies, production and such back on track. Ergo focusing on just getting what countries have and had back in working order once again. Couple that to the debts earned through corona and it doesn't present a system that will be ripe to invest heavily into preparations for the "next" disaster. Instead it presents a system that will likely take years to reach such an affluent point once again.

So it would make sense that cheaper overseas imports and local storage would be more attractive than investment into factories and production that would cost more to source locally. At best we might see designs for emergancy production facilities being drawn up and concepts being used on how quickly we could ramp up required production on short notice. So you might see some raw material buying and storing.

 BobtheInquisitor wrote:
I can relate to this woman’s story.

https://www.washingtonpost.com/nation/2020/07/18/covid-pandemic-store-clerk-north-carolina/?arc404=true

It was only a few pages back when I related my wife's very similar experiences to this poor woman that someone flat out denied that it happened unless it was because my wife had gakky customer service skills.
People can be really, really selfish and take their frustration out over the most minor inconveniences on the poor sod who has to face this sort of thing day in, day out.

I'll take my apology now.

There is a big part of america that straight believes that rights means "I get to do what i want and no one can stop me"
And its true and something i can admire, you have the right to be an idiot and set off a firework in your hand.
But, the problem comes when that same firework is being done in a county notorious for wildfires and in a dry frield. Suddeny you are not just harming yourself, but others too.
Your rights end when you put others in danger.

Trump is now apparently pushing masks (not the one-off at Walter Reed). As much as I'd like to point out the obvious in terms of his prior behavior and how many infected and people were OK until his polling wasn't, and so on, ultimately all that really matters is that now both major political figures in the US are pushing mask wearing when you cannot distance, which is a good thing.

It's not where I'd like for us to be, but it's at least finally sorta heading in the right direction.

Wait, no, not that direction.

So if a vaccine is produced and goes out to the public, what will we do about the wave of autism?

Treat them like normal and not get worried because there are tools and therapies that can help with behaviors associated with autism.
Oh wiat you meant AUTISM!!!!!! the big boogie man of antivaxxers that is a death sentence for young kids and the worst thing to happen to anyone anywhere ever.

Speaking of worst thing ever, Coronavirus infections have been linked to long term erectile dysfunction.

Now there’s a dilemma.

 hotsauceman1 wrote:

 ScarletRose wrote:

 Dreadwinter wrote:
Schools are reopening here in the Fall. Sports conditioning has already started at the High School. Football Conditioning has already been suspended because of a positive Covid test on the team. This Fall is going to be HYPE!

Feth them kids. Let em die! I need my sportsball!

But Dread, one of those kids could get a sports scholarship. So it's totally worth risking the health of the players, staff and family members!

/s

Dude dont get off topic, we can talk about head injuries in sports players in another thread.......
OH, you do mean covid, my bad.


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 Dreadwinter wrote:

I just checked and two more have it. I didn't think they would make an announcement about it on the radio here at 9PM. This is Sunday in a VERY rural and VERY christian area. We cannot even buy alcohol here on Sundays, our Walmart has no liquor license. Things must be getting real. The locals are getting frightened.....

Edit: Random Capitalization

Wait.....the RADIO announced school football changes?

Yeah, the local Radio Station announced it on their Facebook Account. BTW, the guy running the station hates "social media" and he thinks it is ruining the world. I live in a special place.

I managed to find some made in UK masks. They are more expensive than the generic Chinese made masks, but I don't need a lot because I won't be going shopping and so on very much.

Things aren't going back to normal for a long time. Maybe not ever. I hope not.

I don't like the "normal" of spending over 15 hours and £60 a week simply going to the office and home again, when I can do my job equally well in my pyjamas. Why would I want to go back to "normal" even if there wasn't a danger of getting infected?

 Kilkrazy wrote:
I managed to find some made in UK masks. They are more expensive than the generic Chinese made masks, but I don't need a lot because I won't be going shopping and so on very much.

Things aren't going back to normal for a long time. Maybe not ever. I hope not.

I don't like the "normal" of spending over 15 hours and £60 a week simply going to the office and home again, when I can do my job equally well in my pyjamas. Why would I want to go back to "normal" even if there wasn't a danger of getting infected?

There is something to say about knowing your co workers.

My job was implementing telehealth long before this, this thing just speed it up.

Yes, I agree with you. What I think will happen is that we will go back to working perhaps one or two days a week in the office, and working from home the rest of the time. Some businesses will go virtual. They will just hire office space for their weekly meetings.

But "return to normality" wants us all working in the office every day, burning petrol or bus fares to get there, and buying lots of coffee and sandwiches. That isn't going to happen.

City centre businesses are like the dinosaurs now. I don't wish it upon them, but it's the new world.

GoatboyBeta wrote:

tneva82 wrote:

Oxford vaccine is showing increase in resistance to virus though how lasting is next step. Fairly safe though 70% receivers gets fever or headache but treatable level with standard medicines

I'd take those side effects in a heartbeat if a vaccine gave resistance.

True. Good tradeoff since usual self medication sorts those out. It's just Q of how LONG that resistance lasts. that's what they are testing out now. Vaccine isn't much use if it lasts like a month at most.


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 NinthMusketeer wrote:
So if a vaccine is produced and goes out to the public, what will we do about the wave of autism?

For your sake I'm hoping you are joking.

 hotsauceman1 wrote:
Treat them like normal and not get worried because there are tools and therapies that can help with behaviors associated with autism.
Oh wiat you meant AUTISM!!!!!! the big boogie man of antivaxxers that is a death sentence for young kids and the worst thing to happen to anyone anywhere ever.

i am fairly sure, that he was jokingly and humoristicly ,pointing to the obvious issues associated with these groups and the corresponding issues, associated with mandatory vaccination etc.


However, yes, this, considering these people also are allready somewhat normally socialized, one would assume them catching autism, through dark magic because you don't get it from vaccines but just humoristically entertaining that thought, the effects would be marginal.